Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

Reilly SN., Liu X., Carnicer R., Recalde A., Muszkiewicz A., Jayaram R., Carena MC., Wijesurendra R., Stefanini M., Surdo NC., Lomas O., Ratnatunga C., Sayeed R., Krasopoulos G., Rajakumar T., Bueno-Orovio A., Verheule S., Fulga TA., Rodriguez B., Schotten U., Casadei B.

Atrial microRNA-31 up-regulation causes dystrophin and nNOS depletion, which in turn contributes to the electrical phenotype of atrial fibrillation.

DOI

10.1126/scitranslmed.aac4296

Type

Journal article

Publisher

American Association for the Advancement of Science (AAAS)

Publication Date

2016-05-25T00:00:00+00:00

Volume

8

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