Hayley Belnoue-Davis
Senior post-doctoral researcher and lab manager
Research summary
I am currently working on CRUK funded programme “Stem cells and adaptive molecular phenotype in colorectal cancer (STAMP-CRC)” which seeks to explore the impact of therapeutic selective pressures on stem cell molecular phenotype and target the pathways that enable the rapid evolution of drug resistance.
Recent publications
Gil Vazquez E, Nasreddin N, Valbuena GN, Mulholland EJ, Belnoue-Davis HL, Eggington HR, Schenck RO, Wouters VM, Wirapati P, Gilroy K, Lannagan TRM, Flanagan DJ, Najumudeen AK, Omwenga S, McCorry AMB, Easton A, Koelzer VH, East JE, Morton D, Trusolino L, Maughan T, Campbell AD, Loughrey MB, Dunne PD, Tsantoulis P, Huels DJ, Tejpar S, Sansom OJ, Leedham SJ. Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia. Cell Stem Cell. 2022 Nov 3;29(11):1612. doi: 10.1016/j.stem.2022.09.005.
Koppens MA*, Davis H*, Valbuena GN, Mulholland EJ, Nasreddin N, Colombe M, Antanaviciute A, Biswas S, Friedrich M, Lee L; Oxford IBD cohort investigators, Wang LM, Koelzer VH, East JE, Simmons A, Winton DJ, Leedham SJ. BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration. Gastroenterology. 2021 Jul;161(1):239-254.e9. doi: 10.1053/j.gastro.2021.03.052. Epub 2021 Apr 2
Recent publications
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Molecular mechanism of BMP signal control by Twisted gastrulation
Journal article
Malinauskas T. et al, (2024), Nature Communications, 15
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Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis
Journal article
Brown M. et al, (2023), EMBO Molecular Medicine
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Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
Journal article
Flanagan DJ. et al, (2023), Nature Communications, 14
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Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
Journal article
Flanagan DJ. et al, (2022), Nature Communications, 13
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Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.
Journal article
Vasquez EG. et al, (2022), Cell stem cell, 29, 1213 - 1228.e8