Melanie Dunstan
Postdoctoral Research Scientist
I joined the DIL in 2017 as an Oxford-Bristol Myers Squibb (formerly Celgene) Fellow. My research is focused on single-cell analysis of gut-resident T cells in type 1 diabetes and coeliac disease. In addition, I am determining the responses of gut-resident regulatory T cells to Bristol Myers Squibb’s novel IL-2 mutein Fc fusion protein.
Prior to joining the DIL I undertook PhD and post-doctoral research in the UK Dementia Research Institute in Cardiff (Alzheimer’s Disease Group). During this time, I developed cell models to interrogate the biological mechanisms underpinning genetic loci associated with late-onset Alzheimer’s disease.
Recent publications
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Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis
Journal article
Trzupek D. et al, (2020), Genome Medicine, 12
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Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study
Journal article
Prins BP. et al, (2016), PLOS Medicine, 13, e1001976 - e1001976
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Shared genetic contribution to ischemic stroke and Alzheimer's disease
Journal article
Traylor M. et al, (2016), Annals of Neurology, 79, 739 - 747
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A novel Alzheimer disease locus located near the gene encoding tau protein
Journal article
Jun G. et al, (2016), Molecular Psychiatry, 21, 108 - 117
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Convergent genetic and expression data implicate immunity in Alzheimer's disease
Journal article
Jones L. et al, (2015), Alzheimer's & Dementia, 11, 658 - 671