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We have investigated the in vitro susceptibility of the human malaria parasite Plasmodium falciparum to killing by nitric oxide and related molecules. A saturated solution of nitric oxide did not inhibit parasite growth, but two oxidation products of nitric oxide (nitrite and nitrate ions) were toxic to the parasite in millimolar concentrations. Nitrosothiol derivatives of cysteine and glutathione were found to be about a thousand times more active (50% growth inhibitory concentration, approximately 40 microM) than nitrite.


Journal article


Infection and immunity

Publication Date





3280 - 3283


Division of Cell Biology, John Curtin School of Medical Research, Canberra, A.C.T., Australia.


Animals, Plasmodium falciparum, Nitric Oxide, Nitroso Compounds, Colony Count, Microbial, Lethal Dose 50