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4 more cases of cardiotoxicity associated to 5-FU or oral fluoropirimidine (Ptorafur, UFT) in patients without previous heart disease (except in one case) are presented. The toxicity found was myocardial ischemia and EKG changes (in 3 patients) in patients whose enzymes were measured. The etiopathogenesis and features of this toxicity are discussed.


Journal article


Anales de medicina interna (Madrid, Spain : 1984)

Publication Date





525 - 527


Servicio de Medicina Interna, Hospital General Universitario, Valencia.


Humans, Heart Diseases, Fluorouracil, Tegafur, Administration, Oral, Aged, Middle Aged, Male