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The ECL gene detection system is a novel, sensitive, non-radioactive system for the detection of nucleic acid hybridized on both nylon and nitrocellulose membranes. It is characterized by direct labeling of probe sequences with horseradish peroxidase combined with an enhanced chemiluminescent (ECL) detection reaction; the light output is captured on blue-light sensitive film. The application of the system to a range of standard molecular biology hybridization techniques is described.


Journal article



Publication Date





564 - 570


Amersham International plc., Amersham, Bucks, U.K.


Multiple Myeloma, Horseradish Peroxidase, Nucleic Acids, Nucleic Acid Probes, Blotting, Northern, Blotting, Southern, Luminescent Measurements, Nucleic Acid Hybridization, Genes, ras