Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling.
Domingues N., Calcagni' A., Pires J., Freire SR., Herz NJ., Huynh T., Wieciorek K., Moreno MJ., Outeiro TF., Girão H., Milosevic I., Ballabio A., Raimundo N.