Epistasis between the haptoglobin common variant and α+thalassemia influences risk of severe malaria in Kenyan children
Atkinson SH., Uyoga SM., Nyatichi E., Macharia AW., Nyutu G., Ndila C., Kwiatkowski DP., Rockett KA., Williams TN.
<jats:title>Key Points</jats:title> <jats:p>Epistasis between the haptoglobin (Hp) common variants and α+thalassemia predicts the risk of severe malaria in Kenyan children. The inconsistent relationship between Hp type and malaria reported in previous studies may be explained by this epistatic interaction.</jats:p>