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CONTEXT: Approximately 39% of cases with permanent neonatal diabetes (PNDM) and about 11% with maturity onset diabetes of the young (MODY) have an unknown genetic aetiology. Many of the known genes causing MODY and PNDM were identified as being critical for beta cell function before their identification as a cause of monogenic diabetes. OBJECTIVE: We used nominations from the EU beta cell consortium EURODIA project partners to guide gene candidacy. SUBJECTS: Seventeen cases with permanent neonatal diabetes and 8 cases with maturity onset diabetes of the young. MAIN OUTCOME MEASURES: The beta cell experts within the EURODIA consortium were asked to nominate 3 "gold", 3 "silver" and 4 "bronze" genes based on biological or genetic grounds. We sequenced twelve candidate genes from the list based on evidence for candidacy. RESULTS: Sequencing ISL1, LMX1A, MAFA, NGN3, NKX2.2, NKX6.1, PAX4, PAX6, SOX2, SREBF1, SYT9 and UCP2 did not identify any pathogenic mutations. CONCLUSION: Further work is needed to identify novel causes of permanent neonatal diabetes and maturity onset diabetes of the young utilising genetic approaches as well as further candidate genes.

Type

Journal article

Journal

JOP : Journal of the pancreas

Publication Date

08/01/2010

Volume

11

Pages

14 - 17

Addresses

Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, United Kingdom.

Keywords

Humans, Diabetes Mellitus, Sequence Analysis, DNA, DNA Mutational Analysis, Gene Frequency, Polymorphism, Single Nucleotide, Expert Testimony, Adolescent, Adult, Middle Aged, Child, Child, Preschool, Female, Male, Insulin-Secreting Cells, Young Adult