Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase
Reilly SN., Liu X., Carnicer R., Recalde A., Muszkiewicz A., Jayaram R., Carena MC., Wijesurendra R., Stefanini M., Surdo NC., Lomas O., Ratnatunga C., Sayeed R., Krasopoulos G., Rajakumar T., Bueno-Orovio A., Verheule S., Fulga TA., Rodriguez B., Schotten U., Casadei B.
Atrial microRNA-31 up-regulation causes dystrophin and nNOS depletion, which in turn contributes to the electrical phenotype of atrial fibrillation.