Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1.

Beach C., MacLean D., Majorova D., Melemenidis S., Nambiar DK., Kim RK., Valbuena GN., Guglietta S., Krieg C., Darvish-Damavandi M., Suwa T., Easton A., Hillson LV., McCulloch AK., McMahon RK., Pennel K., Edwards J., O'Cathail SM., Roxburgh CS., Domingo E., Moon EJ., Jiang D., Jiang Y., Zhang Q., Koong AC., Woodruff TM., Graves EE., Maughan T., Buczacki SJ., Stucki M., Le Q-T., Leedham SJ., Giaccia AJ., Olcina MM.

DOI

10.1172/jci185067

Type

Journal article

Journal

The Journal of clinical investigation

Publication Date

08/2024

Volume

134

Keywords

Animals, Humans, Mice, Neoplasms, Receptor, Anaphylatoxin C5a, Tumor Microenvironment

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