Deletion of Interleukin-4 Receptor Alpha-Responsive Keratinocytes in BALB/c Mice Does Not Alter Susceptibility to Cutaneous Leishmaniasis
Govender M., Hurdayal R., Martinez-Salazar B., Gqada K., Pillay S., Gcanga L., Passelli K., Nieuwenhuizen NE., Tacchini-Cottier F., Guler R., Brombacher F.
The skin microenvironment at the site of infection plays a role in the early events that determine protective T helper 1/type 1 immune responses during cutaneous leishmaniasis (CL) infection. During CL in nonhealing BALB/c mice, early interleukin-4 (IL-4) can instruct dendritic cells for protective Th1 immunity.