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Found 103 matches for

Common virus may improve skin cancer treatment outcomes

May is Skin Cancer Awareness Month, and a new study with input from researchers in the CHG has revealed that a common virus may positively influence how skin cancer patients respond to current treatments.

David Church awarded a Cancer Research UK Senior Cancer Research Fellowship

David Church received a Senior Cancer Research Fellowship from the Cancer Research UK Research Careers Committee to study MHC-I and MHC-II dysregulation in colorectal & endometrial cancer.

Study finds previously unidentified genetic determinants of rare disease

A landmark study involving researchers from the Centre for Human Genetics has identified 69 previously unidentified genetic determinants of rare disease, including uncommon forms of epilepsy and schizophrenia.

At-home test could play key role in type-1 diabetes screening

A new home test to diagnose type-1 diabetes (T1D) is being investigated in a major UK study led by researchers at the National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre and NDM's Centre for Human Genetics.

Bowel cancer prediction test for IBD patients 90% accurate

Researchers in the CHG have authored a collaborative study which explored a new method for detecting bowel cancer, which was found to be more than 90% accurate at predicting which higher-risk people will develop this type of cancer in the future.

Oxford and GSK launch £50m programme to advance cancer research

Global biopharma company GSK invests up to £50 million in a collaboration with Oxford to advance the understanding of how cancer develops, which could inform future development of vaccines to prevent cancer.

Toxic Cargoes Contributing to Dementia are Contained Within Extracellular Vesicles

New research led by Dr Steph Fowler (UCL and now Oxford IMCM), Professor Karen Duff (UKDRI, UCL), with Dr Benjamin Ryskeldi-Falcon and Dr Tiana Behr (MRC LMB), have shed light on a potential pathway for the spread of harmful tau protein in Alzheimer's disease. Their findings, published in Nature Neuroscience, focus on structures called extracellular vesicles and their role in transporting toxic tau fragments.

New blood test could enable early detection of multiple cancers

A new blood test – powered by machine learning – has shown real promise in detecting multiple types of cancer in their earliest stages, when the disease is hardest to detect. Developed by a team of researchers and co-lead by the Centre for Human Genetics’ Dr Dimitris Vavoulis, the test accurately detected six cancer types and could distinguish between people with and without cancer.

DPhil student Grace Hood awarded Dr. Gregory D. Bossart Memorial One Health Scholarship 2024

The $5000 Scholarship Award for 2024 was granted to Dr. Grace Hood for her One Health Project titled "Deforestation as a driver of emerging viral spillover events at the human-animal-environment interface in Malaysian Borneo"

A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

A pioneering study published in Nature Immunology offers unprecedented insights into cellular responses to common treatments, paving the way to transform the treatment landscape for these chronic inflammatory conditions.

Possible new transmission route for highly pathogenic avian influenza

A new study published in Nature Communications has identified a new potential transmission route for H5 highly pathogenic avian influenza viruses (HPAI). Understanding actual “bird flu” rates in humans will help prevent further spillover and a potential new pandemic.

DPhil Study into the cellular basis of Human Endometrial Cells could progress the development of therapeutics for endometriosis

Magda Mareckova, a DPhil Student working with Prof Krina Zondervan, has created single-cell reference atlas of the human endometrium. The study was published in Nature Genetics.

New disease-inducing mechanism for inflammatory bowel disease (IBD) identified

A study, published by the New England Journal of Medicine, has identified a new disease-inducing mechanism for inflammatory bowel disease (IBD) in which the immune system attacks its own regulatory function.

Developing the first cancer prevention vaccine for Lynch syndrome

Scientists from the Centre for Human Genetics at Nuffield Department of Medicine are taking the initial steps in developing the UK’s first vaccine to prevent cancer in people with Lynch syndrome, thanks to funding from Cancer Research UK.

New shingles vaccine could reduce risk of dementia

The new recombinant shingles vaccine ‘Shingrix’ is associated with a reduced risk of dementia compared to an earlier shingles vaccine, according to a major new study published in Nature Medicine.

New discovery renews hope for thousands with neurodevelopment disorders

A global collaboration led by scientists at the University of Oxford has discovered that genetic variants in a specific gene cause a rare neurodevelopmental disorder (NDD). NDD is a collective term for severe impairments in how the brain functions that impact learning, behaviour, speech, and movement. Most NDDs are thought to be genetic and caused by changes to DNA, however, to date, around 60% of individuals with these conditions do not know the specific DNA change that causes their disorder.

Novel data method sheds light on hidden patterns of kidney inflammation

Globally kidney disease is forecast to be the 5th leading cause of death by 2040, and in the UK more than 3 million people are living with the most severe stages of chronic kidney disease. Chronic kidney disease is often due to autoimmune damage to the filtration units of the kidney, known as the glomeruli, which can occur in lupus, a disease which disproportionally affects women and people of non-white ethnicities, groups often underrepresented in research. Treatment options are limited, can have life threatening side-effects and often don’t slow the disease, which can then progress to end stage, requiring dialysis or a kidney transplant.

Study highlights importance of ‘junk’ DNA in unlocking diagnosis

A recent study led by the Centre for Human Genetics at NDM has revealed that areas of the human genome that are routinely overlooked in clinical tests may be the cause of some rare diseases.

Partnership with Danaher paves way for precision medicine test for sepsis

The University of Oxford today announced a partnership with Danaher Corporation to develop a new test to enable precision medicine care for sepsis, a pathological immune response to infection that accounts for one in five deaths globally each year.

Genetic signals causing ankylosing spondylitis uncovered in a new study

A study by Nuffield Department of Medicine’s Wellcome Centre for Human Genetics, and collaborating researchers have uncovered the genetic signals that cause ankylosing spondylitis, a type of spinal arthritis.

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