Contact information
Research groups
Harindra Amarasinghe
Postdoctoral Scientist
I completed my PhD on epigenetics and the evolution of genomic imprinting at the Department of Genetics and Genome Biology (University of Leicester). I then joined the School of Cancer Sciences of the University of Southampton as a Postdoctoral Research Fellow where I investigated the clinical utility of genetic and epigenetic biomarkers in treating Chronic Lymphocytic Leukaemia patients entered into first-line chemotherapy and chemo-immunotherapy in UK CLL clinical trials.
I joined the Knight group in 2018 and my project explored the role functional genomics play in extreme immunity, with a particular emphasis on immune tolerance, and targeted identification of therapeutic options using a combination of multi-omic approaches.
Currently, I work as a senior scientist in the Knight group on a collaborative project led by Julian Knight and Marian Knight on advancing personalised maternal healthcare using genomic-based approaches alongside epidemiological studies.
Recent publications
Mapping the epigenomic landscape of human monocytes following innate immune activation reveals context-specific mechanisms driving endotoxin tolerance
Journal article
Amarasinghe HE. et al, (2023), BMC Genomics, 24
Telomere Length and DNA Methylation Epitype Both Provide Independent Prognostic Information in CLL Patients; Data from the UK CLL4, Arctic and Admire Clinical Trials
Journal article
Carr LJ. et al, (2023), BLOOD, 142
Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance
Journal article
Zhang P. et al, (2022), Genome Biology, 23
Clinico-biological significance of DNA methylation in chronic lymphocytic leukaemia patients: results from three UK clinical trials
Conference paper
Rose-Zerilli M. et al, (2020), LEUKEMIA & LYMPHOMA, 61, 100 - 102
Abstract 3306: The clinical importance of DNA methylation signatures in chronic lymphocytic leukemia patients treated with chemo-immunotherapy
Conference paper
Wojdacz TK. et al, (2018), Cancer Research, 78, 3306 - 3306