Genome-wide studies identify a novel interplay between AML1 and AML1/ETO in t(8;21) acute myeloid leukemia
Li Y., Wang H., Wang X., Jin W., Tan Y., Fang H., Chen S., Chen Z., Wang K.
<jats:title>Key Points</jats:title> <jats:p>Wild-type AML1 and AML1/ETO form a complex on chromatin via binding to adjacent different motifs and interacting through the runt homology domain. The relative binding signals of AML1/ETO and AML1 and AP-1 recruitment determine whether AML1/ETO activates or represses its targets.</jats:p>