Search results (10)
« Back to NewsToxic Cargoes Contributing to Dementia are Contained Within Extracellular Vesicles
17 January 2025
New research led by Dr Steph Fowler (UCL and now Oxford IMCM), Professor Karen Duff (UKDRI, UCL), with Dr Benjamin Ryskeldi-Falcon and Dr Tiana Behr (MRC LMB), have shed light on a potential pathway for the spread of harmful tau protein in Alzheimer's disease. Their findings, published in Nature Neuroscience, focus on structures called extracellular vesicles and their role in transporting toxic tau fragments.
New blood test could enable early detection of multiple cancers
8 January 2025
A new blood test – powered by machine learning – has shown real promise in detecting multiple types of cancer in their earliest stages, when the disease is hardest to detect. Developed by a team of researchers and co-lead by the Centre for Human Genetics’ Dr Dimitris Vavoulis, the test accurately detected six cancer types and could distinguish between people with and without cancer.
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease
22 October 2024
A pioneering study published in Nature Immunology offers unprecedented insights into cellular responses to common treatments, paving the way to transform the treatment landscape for these chronic inflammatory conditions.
DPhil Study into the cellular basis of Human Endometrial Cells could progress the development of therapeutics for endometriosis
16 October 2024
Magda Mareckova, a DPhil Student working with Prof Krina Zondervan, has created single-cell reference atlas of the human endometrium. The study was published in Nature Genetics.
New shingles vaccine could reduce risk of dementia
25 July 2024
The new recombinant shingles vaccine ‘Shingrix’ is associated with a reduced risk of dementia compared to an earlier shingles vaccine, according to a major new study published in Nature Medicine.
New discovery renews hope for thousands with neurodevelopment disorders
15 July 2024
A global collaboration led by scientists at the University of Oxford has discovered that genetic variants in a specific gene cause a rare neurodevelopmental disorder (NDD). NDD is a collective term for severe impairments in how the brain functions that impact learning, behaviour, speech, and movement. Most NDDs are thought to be genetic and caused by changes to DNA, however, to date, around 60% of individuals with these conditions do not know the specific DNA change that causes their disorder.
Novel data method sheds light on hidden patterns of kidney inflammation
20 June 2024
Globally kidney disease is forecast to be the 5th leading cause of death by 2040, and in the UK more than 3 million people are living with the most severe stages of chronic kidney disease. Chronic kidney disease is often due to autoimmune damage to the filtration units of the kidney, known as the glomeruli, which can occur in lupus, a disease which disproportionally affects women and people of non-white ethnicities, groups often underrepresented in research. Treatment options are limited, can have life threatening side-effects and often don’t slow the disease, which can then progress to end stage, requiring dialysis or a kidney transplant.
COVID-19 Multi-omic Blood Atlas (COMBAT) published
3 March 2022
The COVID-19 Multi-omic Blood Atlas (COMBAT) defines hallmarks of disease severity and specificity
Researchers find genetic ‘fingerprints’ of ancient migrations in modern-day United Arab Emirates
28 February 2022
A team of geneticists and archaeologists have analysed the fine-scale genetic structure and ancestry of nearly 1200 people from the United Arab Emirates (UAE), and found genetic traces of population mixing spanning thousands of years.
Researchers identify genetic cause of endometriosis and potential drug target
31 August 2021
Endometriosis is a painful, chronic condition in which tissue from the uterus inappropriately grows outside the uterus.