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« Back to NewsNew disease-inducing mechanism for inflammatory bowel disease (IBD) identified
11 September 2024
A study, published by the New England Journal of Medicine, has identified a new disease-inducing mechanism for inflammatory bowel disease (IBD) in which the immune system attacks its own regulatory function.
Developing the first cancer prevention vaccine for Lynch syndrome
10 September 2024
Scientists from the Centre for Human Genetics at Nuffield Department of Medicine are taking the initial steps in developing the UK’s first vaccine to prevent cancer in people with Lynch syndrome, thanks to funding from Cancer Research UK.
New shingles vaccine could reduce risk of dementia
25 July 2024
The new recombinant shingles vaccine ‘Shingrix’ is associated with a reduced risk of dementia compared to an earlier shingles vaccine, according to a major new study published in Nature Medicine.
New discovery renews hope for thousands with neurodevelopment disorders
15 July 2024
A global collaboration led by scientists at the University of Oxford has discovered that genetic variants in a specific gene cause a rare neurodevelopmental disorder (NDD). NDD is a collective term for severe impairments in how the brain functions that impact learning, behaviour, speech, and movement. Most NDDs are thought to be genetic and caused by changes to DNA, however, to date, around 60% of individuals with these conditions do not know the specific DNA change that causes their disorder.
Novel data method sheds light on hidden patterns of kidney inflammation
20 June 2024
Globally kidney disease is forecast to be the 5th leading cause of death by 2040, and in the UK more than 3 million people are living with the most severe stages of chronic kidney disease. Chronic kidney disease is often due to autoimmune damage to the filtration units of the kidney, known as the glomeruli, which can occur in lupus, a disease which disproportionally affects women and people of non-white ethnicities, groups often underrepresented in research. Treatment options are limited, can have life threatening side-effects and often don’t slow the disease, which can then progress to end stage, requiring dialysis or a kidney transplant.
Study highlights importance of ‘junk’ DNA in unlocking diagnosis
18 January 2024
A recent study led by the Centre for Human Genetics at NDM has revealed that areas of the human genome that are routinely overlooked in clinical tests may be the cause of some rare diseases.
Partnership with Danaher paves way for precision medicine test for sepsis
8 November 2023
The University of Oxford today announced a partnership with Danaher Corporation to develop a new test to enable precision medicine care for sepsis, a pathological immune response to infection that accounts for one in five deaths globally each year.
Genetic signals causing ankylosing spondylitis uncovered in a new study
26 April 2023
A study by Nuffield Department of Medicine’s Wellcome Centre for Human Genetics, and collaborating researchers have uncovered the genetic signals that cause ankylosing spondylitis, a type of spinal arthritis.
New study reveals significant clues for targeted therapies for sepsis
24 April 2023
Researchers from NDM’s Wellcome Centre for Human Genetics and the Queen Mary University have found evidence of how the normally protective response of the immune system to infection can go wrong in sepsis, offering exciting possibilities for the development of more targeted therapies for this deadly condition.
COVID-19 Multi-omic Blood Atlas (COMBAT) published
3 March 2022
The COVID-19 Multi-omic Blood Atlas (COMBAT) defines hallmarks of disease severity and specificity