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Dr Carol Nathali Flores Fernandez

Co-Principal Investigator in Molecular and Synthetic Biology

  • Dr Nathali Flores is a Senior Researcher at the University of Oxford. In her position, Dr Flores is working on the development and improvement of an innovative DNA assembly technology for the synthesis of large DNA molecules. Her primary role is to supervise, coordinate and execute activities and budgets within Professor Chris O’Callaghan’s group and manage collaborative work with other research groups. Dr Flores has broad research experience in molecular and synthetic biology, biotechnology and biochemistry.
  • In mid-2025, Dr Flores was awarded grant funding with Prof. Chris O’Callaghan from the Advanced Research and Invention Agency (ARIA), to develop synthetic organelle genomes. In 2016, she was awarded funding as a Researcher at University College London, UK and from 2015 to 2017 at Major National University of San Marcos, Peru.
  • Nathali Flores completed her PhD studies in Biochemical Engineering at University College London. Her PhD project, which won the 1st Prize in her cohort, was focused on the genome-mining and discovery of novel extremozymes for recycling sustainable biomass within a biorefineries context. She was awarded the Republic President Scholarship by the Minister of Education of Peru to study her PhD abroad, achieving the 1st Prize.
  • Dr Nathali Flores has supervised several students, authored a number of peer-reviewed publications, participated in conference papers and proceedings and peer-reviewed manuscripts.

Research

My research aims to achieve the synthesis of large DNA molecules regardless of their nature or sequence using the UniClo technology we developed in Prof. Chris O’Callaghan group. Using this technology, it is possible to rapidly and simply assemble DNA molecules up to hundreds of thousands of base pairs in length. We are developing this technology to make it simpler, more time-effective and flexible. We are also creating an intuitive and user-friendly platform to make it accessible. The initial application of this technology has been focused on generating synthetic organelle genomes. However, it has many other potential applications in medicine, agriculture and biotechnology that we are keen to pursue.

Publications