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Wellcome Centre for Human Genetics

Structure-based classification of paramyxoviral attachment glycoproteins reflects receptor specificity.

Thomas Bowden

Professor of Structural Biology

Structural biology of antibodies and viral glycoproteins

Glycoproteins feature on the surface of many enveloped viruses, and as such, are attractive targets for therapeutic design. Through the application of techniques in structural biology, immunology, and cell biology, our group aims to harness knowledge of glycoprotein structure and function to inform upon the rational development of therapeutics and preventive medicines. We have a particular interest in the development and characterisation of neutralising and protective monoclonal antibodies and look to apply the insights gleaned from our biophysical studies to identify sites of vulnerability that may be targeted through rational vaccine design.

Recent publications

Structural basis for recognition of Rift Valley fever virus Gn protein by a human neutralizing monoclonal antibody with a kappa light chain.

Paesen GC. et al, (2026), PLoS pathogens, 22

Molecular basis for occlusion of the jeilongvirus receptor-binding site by the elongated C-terminus

Stelfox AJ. et al, (2026), mBio, 17

Structure-guided loop grafting improves expression and stability of influenza neuraminidase for vaccine development

Rijal P. et al, (2025), eLife, 14

Structure-guided loop grafting improves expression and stability of influenza neuraminidase for vaccine development

Rijal P. et al, (2025), eLife, 14

Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex

Paesen GC. et al, (2025), mBio, 16

Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex

Paesen GC. et al, (2024)

A monoclonal antibody targeting the Nipah virus fusion glycoprotein apex imparts protection from disease.

Avanzato VA. et al, (2024), Journal of virology, 98

Central tolerance shapes the neutralizing B cell repertoire against a persisting virus in its natural host.

Florova M. et al, (2024), Proceedings of the National Academy of Sciences of the United States of America, 121

Structure guided mutagenesis of Henipavirus Receptor Binding Proteins reveals molecular determinants of receptor usage and antibody binding epitopes

Oguntuyo KY. et al, (2023)

Crystal structure and solution state of the C-terminal head region of the narmovirus receptor binding protein

Stelfox AJ. et al, (2023), mBio, 14

Experimental phasing opportunities for macromolecular crystallography at very long wavelengths

El Omari K. et al, (2023), Communications Chemistry, 6

Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses.

Chapman NS. et al, (2023), Nature communications, 14

Mechanistic basis for potent neutralization of Sin Nombre hantavirus by a human monoclonal antibody

Stass R. et al, (2023), Nature Microbiology, 8, 1293 - 1303

Identification of Evolutionary Trajectories Shared across Human Betacoronaviruses

Escalera-Zamudio M. et al, (2023), Genome Biology and Evolution, 15

VelcroVax: a "Bolt-On" Vaccine Platform for Glycoprotein Display.

Kingston NJ. et al, (2023), mSphere, 8

Crystal structure and solution state of the C-terminal head region of the narmovirus receptor binding protein

Stelfox AJ. et al, (2022)

Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies

Ng WM. et al, (2022), mBio, 13

Structure of trimeric pre-fusion rabies virus glycoprotein in complex with two protective antibodies

Ng WM. et al, (2022)

Insertion of atypical glycans into the tumor antigen-binding site identifies DLBCLs with distinct origin and behavior.

Chiodin G. et al, (2021), Blood, 138, 1570 - 1582

Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen

Rissanen I. et al, (2021), mBio, 12

Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant.

Graham C. et al, (2021), Immunity, 54, 1276 - 1289.e6

Identification of evolutionary trajectories shared across human betacoronaviruses

Escalera-Zamudio M. et al, (2021)

Antibody evasion by the P.1 strain of SARS-CoV-2

Dejnirattisai W. et al, (2021), Cell, 184, 2939 - 2954.e9

Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil.

Faria NR. et al, (2021), Science (New York, N.Y.), 372, 815 - 821

Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil.

Faria NR. et al, (2021), medRxiv

Recent Advances in Bunyavirus Glycoprotein Research: Precursor Processing, Receptor Binding and Structure

Hulswit RJG. et al, (2021), Viruses, 13, 353 - 353

Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation

Rahikainen R. et al, (2021), Angewandte Chemie International Edition, 60, 321 - 330

Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein

Rissanen I. et al, (2020), eLife, 9

A novel circulating tamiami mammarenavirus shows potential for zoonotic spillover.

Moreno H. et al, (2020), PLoS neglected tropical diseases, 14

Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer.

Avanzato VA. et al, (2020), Cell, 183, 1901 - 1912.e9

Parallel evolution in the emergence of highly pathogenic avian influenza A viruses

Escalera-Zamudio M. et al, (2020), Nature Communications, 11

Naturally Acquired Rift Valley Fever Virus Neutralizing Antibodies Predominantly Target the Gn Glycoprotein

Wright D. et al, (2020), iScience, 23, 101669 - 101669

Identification of Common Deletions in the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2.

Liu Z. et al, (2020), Journal of virology, 94, e00790 - e00720

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

Watanabe Y. et al, (2020), Nature Communications, 11

Evolutionary Dynamics of Oropouche Virus in South America

Gutierrez B. et al, (2020), Journal of Virology, 94

A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus

Pryce R. et al, (2020), Life Science Alliance, 3, e201900578 - e201900578

Unraveling virus relationships by structure-based phylogenetic classification

Ng WM. et al, (2020), Virus Evolution, 6

A structural basis for antibody-mediated neutralization of Nipah virus reveals a site of vulnerability at the fusion glycoprotein apex.

Avanzato VA. et al, (2019), Proceedings of the National Academy of Sciences of the United States of America, 116, 25057 - 25067

A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters.

van Doremalen N. et al, (2019), PLoS neglected tropical diseases, 13

A potent neutralizing epitope of limited variability in the head domain of haemagglutinin as a novel influenza vaccine target

Thompson CP. et al, (2017)

Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope

Rissanen I. et al, (2017), Journal of Virology, 91

Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses

Rissanen I. et al, (2017), Nature Communications, 8

Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization

Zeltina A. et al, (2017), Proceedings of the National Academy of Sciences, 114, 7031 - 7036

Human antibody pieces together the puzzle of the trimeric Lassa virus surface antigen

Zeltina A. and Bowden TA., (2017), Nature Structural & Molecular Biology, 24, 559 - 560

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Thomas Bowden

Structural biology of antibodies and viral glycoproteins

Recent publications