Switching of Receptor Binding Poses between Closely Related Enteroviruses
Journal article
Zhou D. et al, (2022), Viruses, 14, 2625 - 2625
Structural Analysis and Development of Notum Fragment Screening Hits.
Journal article
Zhao Y. et al, (2022), ACS chemical neuroscience
Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character
Preprint
Powell GT. et al, (2022)
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
Journal article
Willis NJ. et al, (2022), Journal of medicinal chemistry
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity
Journal article
Steadman D. et al, (2021), Journal of Medicinal Chemistry
Antibody evasion by the P.1 strain of SARS-CoV-2
Journal article
Dejnirattisai W. et al, (2021), Cell, 184, 2939 - 2954.e9
Small-molecule inhibitors of carboxylesterase Notum
Journal article
Zhao Y. et al, (2021), Future Medicinal Chemistry
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant.
Journal article
Graham C. et al, (2021), Immunity
The antigenic anatomy of SARS-CoV-2 receptor binding domain
Journal article
Dejnirattisai W. et al, (2021), Cell, 184, 2183 - 2200.e22
Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Journal article
Huo J. et al, (2021), Nature Structural & Molecular Biology, 28, 326 - 326
Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera
Journal article
Zhou D. et al, (2021), Cell
Notum Deacylates Octanoylated Ghrelin
Journal article
Zhao Y. et al, (2021), Molecular Metabolism, 101201 - 101201
Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera
Journal article
Supasa P. et al, (2021), Cell
Caffeine inhibits Notum activity by binding at the catalytic pocket
Journal article
Zhao Y. et al, (2020), Communications Biology, 3
Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Journal article
Huo J. et al, (2020), Nature Structural & Molecular Biology, 27, 1094 - 1094
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit
Journal article
Mahy W. et al, (2020), Journal of Medicinal Chemistry