Taylor group: Translational Genomics
Translation of genetics research into clinical practice
Research overview
Oxford Biomedical Research Centre – Genomic Medicine Theme
Professor Jenny Taylor is Co-Theme Leader of the Genomic Medicine Theme of the Oxford Biomedical Research Centre (BRC), one of several such centres in the UK funded by the National Institute of Health Research with the overarching aim of translating advances in biomedical research into NHS practice.
The aims of the Genomic Medicine Theme are to:
- apply next-generation sequencing technologies (NGS) to the discovery of novel disease genes
- evaluate and develop these technologies for rapid translation into the clinic, resulting in new NHS-based genetics services
- provide genetics and genomics infrastructure (platforms and expertise) to support other translational research projects
Our research is truly multi-disciplinary, integrating researchers and clinicians (particularly those based at the Centre) from a range of medical specialities, with clinical scientists from the diagnostic laboratories, and others, including specialists in health economics, informatics, and ethics.
The activities of the Genomic Medicine Theme are divided into three sub-themes, each with a specific programme of collaborative projects. Members of the Taylor group are involved across all three sub-themes, either running projects of their own or as collaborators in wider programmes.
Clinical applications of sequencing
Our team
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Yesim Kesim
Postdoctoral Researcher
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Peggy Cheung
Executive Assistant and Project Coordinator for the Oxford BRC Genetics Theme
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Prasun Dutta
Senior Bioinformatician
Latest publications
CMS subtypes correlate with complete response in trial of neoadjuvant Galunisertib plus chemoradiation in rectal cancer
Journal article
Rajamanickam V. et al, (2026), Translational Oncology, 66, 102690 - 102690
Plasma extracellular vesicle modulate immune cell transcriptional responses following acute myocardial infarction
Journal article
Timms L. et al, (2026), Iscience, 29
Dopamine release from Parkinson's patient-derived neurons is disrupted due to impaired synaptic vesicle loading
Preprint
Cramb KML. et al, (2026)
Patterns of HIV-1 viral load suppression and drug resistance during the dolutegravir transition: a population-based longitudinal study.
Journal article
Martin MA. et al, (2026), Clin Infect Dis
ESR1 Mutation in Endocrine Treatment-Naïve Endometrial Cancer: Prevalence, Characteristics, and Prognostic Implications, Results from the UTOLA Phase II GINECO Trial
Journal article
Blanc-Durand F. et al, (2026), Clinical Cancer Research, 32, 963 - 969
Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny
Journal article
Hunt M. et al, (2026), Nature Methods, 23, 653 - 662
The Role of Fibroblast–Epithelial Cross-Talk on the Distribution of Distinct Fibroblast Phenotypes in the Intestinal Crypt
Journal article
Atkinson G. et al, (2026), Bulletin of Mathematical Biology, 88
Severe necrotizing soft tissue infections (SENSEI) study: Protocol for a multi-centered audit
Journal article
Yoshimura R. et al, (2026), JPRAS Open, 48, 331 - 336