Contact information
Research groups
Daniel Crouch
Senior Statistical Programmer
I am a statistical geneticist with a background in population genetics and quantitative trait association mapping. I am currently using genetic data to investigate the relationship between type I diabetes and autoimmune thyroid disease, in order to provide insights into the mechanistic basis of the former. I am also analysing data in the UK Biobank, attempting to identify environmental risk factors that lead to type I diabetes.
Previously I have worked on the genetics of human facial features, deriving measurements from 3D photographs, and finding statistical associations of these with DNA variants. As part of this work I developed methods for extracting the most heritable phenotypes from complex, multivariate image data. I have also worked on theories explaining why organisms reproducing sexually have a selective advantage over those that do not.
Recent publications
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Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants
Journal article
Crouch DJM. and Bodmer WF., (2020), Proceedings of the National Academy of Sciences, 202005634 - 202005634
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Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing.
Journal article
Bodmer WF. and Crouch DJM., (2020), Journal of theoretical biology, 489
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Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells.
Journal article
Inshaw JRJ. et al, (2020), Diabetes care, 43, 169 - 177
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Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression
Journal article
Ferreira RC. et al, (2019), Frontiers in Immunology, 10
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Genetics of the human face: Identification of large-effect single gene variants
Journal article
Crouch DJM. et al, (2018), Proceedings of the National Academy of Sciences, 115, E676 - E685