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Daniel Crouch

Senior Statistical Programmer

I am a statistical geneticist with a background in population genetics and quantitative trait association mapping.  I am currently using genetic data to investigate the relationship between type I diabetes and autoimmune thyroid disease, in order to provide insights into the mechanistic basis of the former. I am also analysing data in the UK Biobank, attempting to identify environmental risk factors that lead to type I diabetes.

Previously I have worked on the genetics of human facial features, deriving measurements from 3D photographs, and finding statistical associations of these with DNA variants. As part of this work I developed methods for extracting the most heritable phenotypes from complex, multivariate image data. I have also worked on theories explaining why organisms reproducing sexually have a selective advantage over those that do not.

Recent publications

The false evidence rate: An approach to frequentist error rate control conditioning on the observed P value.

Journal article

Crouch DJM., (2025), Proceedings of the National Academy of Sciences of the United States of America, 122

Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants

Journal article

Crouch DJM. and Bodmer WF., (2020), Proceedings of the National Academy of Sciences, 117, 18924 - 18933

Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing.

Journal article

Bodmer WF. and Crouch DJM., (2020), Journal of theoretical biology, 489