David Church
Professor
- Cancer Research UK Senior Cancer Research Fellow
- Honorary Consultant in Medical Oncology
Research focus
We study the mechanisms underpinning the growth and suppression of bowel and womb cancers, focusing particularly on the immune response tumours induce and evade. We aim to identify new biomarkers and targets to better prevent and treat these common diseases
Key publications
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'Toxgnostics': An unmet need in cancer medicine
Journal article
Church D. et al, (2014), Nature Reviews Cancer, 14, 440 - 445
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Tertiary lymphoid structures critical for prognosis in endometrial cancer patients.
Journal article
Horeweg N. et al, (2022), Nature communications, 13
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The English National Lynch Syndrome transformation project: an NHS Genomic Medicine Service Alliance (GMSA) programme.
Journal article
Monahan KJ. et al, (2023), BMJ oncology, 2
Recent publications
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Spatiotemporal immune landscape and long-term immune memory in POLE-mutant endometrial cancer at the single-cell level
Journal article
Brummel K. et al, (2025), Cancer Immunology Research
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Replication-associated mechanisms contribute to an increased CpG > TpG mutation burden in mismatch repair-deficient cancers
Journal article
Ward JC. et al, (2025), Genome Medicine, 17
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Activin A affects colorectal cancer progression and immunomodulation in a stage dependent manner.
Journal article
Wiley MB. et al, (2025), Scientific reports, 15