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Church group: tumour genomics and immunology

Focus on colorectal and endometrial cancers

Correlative analysis of human tumours

Functional cancer models

We study mechanisms of tumorigenesis and tumour suppression in colorectal and endometrial cancer with focus on the interaction between the tumour (epi)genome and host immune response, particularly in highly mutated tumours. Our aim is to identify new biomarkers and therapeutic targets we can use to improve treatment of these common diseases.

Our work

Church overview

 

 

PREPRINTS

Everall et al. Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types from 10,983 cancer patients (under review)

Cornish et al. Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactions (under review)

 

Collaborations

TransPORTEC group

TransSCOT group

 

Links

Genomics England

 

Our team

Recent publications

All publications