Sybille Marchese
Ph.D
Post-doctoral Researcher (Fowler lab)
Sybille obtained an international Master in Neuroscience from the University of Bordeaux (France) in 2019, where she developed her interest for synaptic biology in health and disease. Her work focused on studying the post-synaptic active zone organisation in neurodevelopmental disorders, using super-resolution imaging techniques (dSTORM) in the lab of Drs Mireille Montcouquiol and Nathalie Sans (Institut François Magendie, Bordeaux Neurocampus, France).
Following this, she moved to Scotland for her PhD in late 2019, in the newly-established lab of Dr. Juan Varela at the University of St. Andrews. There, she investigated early receptor-mediated mechanisms leading to neuronal dysfunction in Alzheimer’s Disease. Using multiple imaging techniques, ranging from single molecule localisation microscopy (SMLM, PAINT) to live imaging of primary neurons (calcium and single-particle tracking), she discovered that precisely characterised, different populations of Amyloid β oligomers alter PirB sub-cellular localisation and thus neuronal plasticity in hippocampal neurons. Her PhD was awarded in March 2024.
She joined Dr Steph Fowler’s lab at the Oxford-GSK Institute of Molecular and Computational Medicine (IMCM) in May of 2024 as a post-doctoral researcher. Her work combines spatial proteomics and super-resolution imaging to understand the changes in subcellular localisation of tau following its pathological assembly in iPSC models of tauopathy.