Daniel Crouch
Senior Statistical Programmer
I am a statistical geneticist with a background in population genetics and quantitative trait association mapping. I am currently using genetic data to investigate the relationship between type I diabetes and autoimmune thyroid disease, in order to provide insights into the mechanistic basis of the former. I am also analysing data in the UK Biobank, attempting to identify environmental risk factors that lead to type I diabetes.
Previously I have worked on the genetics of human facial features, deriving measurements from 3D photographs, and finding statistical associations of these with DNA variants. As part of this work I developed methods for extracting the most heritable phenotypes from complex, multivariate image data. I have also worked on theories explaining why organisms reproducing sexually have a selective advantage over those that do not.
Recent publications
The false evidence rate: An approach to frequentist error rate control conditioning on the observed P value.
Journal article
Crouch DJM., (2025), Proceedings of the National Academy of Sciences of the United States of America, 122
Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow-Up Studies.
Journal article
Crouch DJM. et al, (2025), Genetic epidemiology, 49
Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants
Journal article
Crouch DJM. and Bodmer WF., (2020), Proceedings of the National Academy of Sciences, 117, 18924 - 18933
Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing.
Journal article
Bodmer WF. and Crouch DJM., (2020), Journal of theoretical biology, 489
Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells.
Journal article
Inshaw JRJ. et al, (2020), Diabetes care, 43, 169 - 177