Alumni Profile: Emma Wallace (2023-2024)

Before starting the MSc program, I interned at a biotechnology company focused on developing treatments for rare, genetically-defined disease. I assisted with running RNA sequencing experiments and developed a Python program to streamline sequencing data analysis. I also completed an internship at Massachusetts General Hospital, where I investigated genetic and neurobiological alterations in the serotonergic system associated with Autism Spectrum Disorder (ASD). My research identified genetic variants within this system that could be used to personalise treatments for ASD patients. My undergraduate research project focused on understanding epigenetic mechanisms underlying resistance to antifungal treatments in fission yeast. 

WHY DID YOU CHOOSE THE MSC IN GENOMIC MEDICINE AT OXFORD?

My undergraduate background was in molecular genetics, and I found myself increasingly drawn to the translational applications of genetics and genomics research. I find many research areas within the field of genomic medicine very intriguing, and I hoped the MSc course in Genomic Medicine would both expand my knowledge of this field and allow me to develop a more focused research interest. Additionally, I was excited to be a part of a highly interdisciplinary cohort, bringing together individuals with backgrounds in medicine, biology, and computer science. 

WHAT WERE THE HIGHLIGHTS OF THE MSC IN GENOMIC MEDICINE FOR YOU?

The highlight of my MSc course was my thesis project and lab placement in the Higgs-Kassouf group. Submitting my written thesis and delivering a formal presentation felt like major accomplishment, and I enjoyed my time in the lab so much that I eagerly accepted the opportunity to continue as a Research Assistant after completing the course. Another key highlight was my course mates. Being surrounded by like-minded people who I connected with made the experience even more rewarding and positive throughout the year.

WHICH SPECIFIC ADVANCED ELECTIVE MODULES DID YOU CHOOSE, AND WHY?

I chose the following modules: A1 Molecular Pathology and Precision Medicine, A2 Advanced Quantitative Methods (Bioinformatics and Statistics), and B2 Applications of Genomics for Therapeutics, Vaccinology, and Industry. I selected modules based on how they fit in with my interests and their potential to fill in any existing gaps in my knowledge. For example, one of my key goals during this MSc program was to strengthen my skills in computational biology. With that in mind, I saw A2 as an excellent opportunity to explore this area. 

TELL US ABOUT YOUR MSC RESEARCH PROJECT AND HOW IT CONTRIBUTED TO YOUR UNDERSTANDING OF GENOMICS AND RESEARCH SKILLS.

My research project lab focuses on understanding the fundamental principles of gene regulation during mammalian differentiation and development. Gaining insights into these mechanisms is crucial for understanding how they become dysregulated in human disease. My specific project examined factors that influence the strength of insulator elements, which are regulatory genetic elements that shape three-dimensional chromatin architecture and, thereby, gene expression. To address my research question, I utilised both computational and wet-lab approaches. The opportunity to undertake an independent research project, guided and supported by host lab members, was essential to develop fundamental research skill sets, such as troubleshooting experiments, managing scientific protocols, and engaging with scientific literature. 

HOW DO YOU ENVISION THE MSC IN GENOMIC MEDICINE BENEFITING YOUR FUTURE CAREER OR ACADEMIC PURSUITS? 

The MSc provided a strong foundation as I planned my next steps. The opportunity to pursue an independent research project helped me determine whether research was the right path for me, while also allowing flexibility to pivot into related scientific careers. The course enabled me to refine my research focus, gain valuable experience, and build confidence in my skill sets. All of these are helpful throughout a scientific career and, I hope, during my upcoming PhD studies. 

IF YOU COULD OFFER ADVICE TO PROSPECTIVE STUDENTS CONSIDERING THE MSC IN GENOMIC MEDICINE AT OXFORD, WHAT WOULD IT BE?

I highly recommend attending as many scientific talks and seminars as possible. Oxford conducts outstanding research in the field of genetics and genomic medicine, and many of the researchers involved also teach on the MSc course. If you have any questions, don’t hesitate to follow-up and email a speaker. In my experience, people are almost always open to discussions and chats with interested scientists. In fact, I discovered the lab where I completed my MSc thesis project by reaching out after a seminar that interested me!