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Globally kidney disease is forecast to be the 5th leading cause of death by 2040, and in the UK more than 3 million people are living with the most severe stages of chronic kidney disease. Chronic kidney disease is often due to autoimmune damage to the filtration units of the kidney, known as the glomeruli, which can occur in lupus, a disease which disproportionally affects women and people of non-white ethnicities, groups often underrepresented in research. Treatment options are limited, can have life threatening side-effects and often don’t slow the disease, which can then progress to end stage, requiring dialysis or a kidney transplant.
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Fran Monks
Hallegger Group: RNomics in Neurodegeneration
We use sophisticated transcriptomic methods and biophysical approaches to characterise condensation-dependent RNA binding and how this on a molecular level changes RNA regulation to give us better insights into the earliest stages of FTD-ALS disease aetiology.
Lang Group
The focus of the group's research involves developing simple co-culture & complex microfluidic co-culture methods of human induced-pluripotent stem cell-derived neurons & glia to understand communication between these cell types in health and neurodegenerative disease.
Uhlig Group
Paediatric Inflammatory Bowel Disease (IBD) & associated rare immune defects
Douglas Group
Identifying novel genes involved in coronary artery disease.
Oxford Laboratory for Neuroimmunology and Immunopsychiatry
We study neuro-immune interactions
Beagrie Group: Chromatin and Disease
We use cutting-edge genomics approaches to study genetic diseases of chromatin function.
Parks Group: Antibody Genes and Infectious Disease Susceptibility
Diseases caused the human-restricted bacterial pathogen Streptococcus pyogenes.
Lucassen group- CELS Oxford
Clinical Ethics, Law, and Society (CELS) Oxford: An interdisciplinary research group exploring the ethical, legal and social aspects of scientific and technological advances in healthcare
Mentzer Group: Infection Immunogenetics
Researching genetic variants and molecular mechanisms that may be responsible for increasing susceptibility to a range of infectious diseases.
Cornall Group
IMMUNE REGULATION AND PATHOLOGY
O'Callaghan Group: Functional genomics of inflammatory metabolic disease
We aim to identify new disease mechanisms that could form the basis for new treatments. We are particularly interested in understanding how the immune system and inflammation are involved in the development of atherosclerosis and diabetes mellitus. These diseases are common and important and atherosclerosis is the major cause of death globally and an increasing problem even in poorer countries.
Milosevic Group
NEURONAL PHYSIOLOGY AND PATHOLOGY
Carroll Group: High Consequence Emerging Viruses Group
HOST-PATHOGEN INTERACTIONS OF HIGH CONSEQUENCE EMERGING VIRUSES
Whiffin Group: Computational Rare Disease Genomics
We use computational approaches and large genomic datasets to uncover novel genetic variants that cause rare disease, and understand the mechanisms through which they do so.
Crabtree Group: Cardiovascular Redox Biology Group
NOS and BH4 as a redox ‘hub’ in cardiovascular homeostasis and disease.
Bhattacharya Group: Developing novel therapeutics for inflammatory diseases
Our goals are to develop therapeutics targeting the chemokine network in inflammatory diseases affecting the heart, blood vessels and other organ systems.