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NEURONAL PHYSIOLOGY AND PATHOLOGY

Our laboratory investigates fundamental aspects of exocytosis, endocytosis and synaptic vesicle recycling that have relevance to neuronal and brain functions, using mouse and mammalian cells as model systems. We are developing new methodology and combine biochemistry, imaging (light and electron microscopy), cell biology and electrophysiology techniques to study the regulation of synaptic vesicle formation, as well as synaptic vesicle acidification and (re)filling. In a distinct but related line of work, we are exploring the signaling processes that originate from altered synaptic transmission and lead to neurodegeneration, in particular Parkinson's disease. 

 

Our team

Selected publications

Dynamins maintain nuclear envelope homeostasis and genome stability

Journal article

Aveleira C. et al, (2026), Nature Communications, 17

Nucleophagy removes cytotoxic trapped PARP1

Preprint

Hoslett G. et al, (2025)

Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling

Journal article

Domingues N. et al, (2025), EMBO Reports, 26, 6096 - 6120

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment

Journal article

Ogunmowo TH. et al, (2025), Nature Neuroscience, 28, 1649 - 1662