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Our laboratory investigates fundamental aspects of exocytosis, endocytosis and synaptic vesicle recycling that have relevance to neuronal and brain functions, using mouse and mammalian cells as model systems. We are developing new methodology and combine biochemistry, imaging (light and electron microscopy), cell biology and electrophysiology techniques to study the regulation of synaptic vesicle formation, as well as synaptic vesicle acidification and (re)filling. In a distinct but related line of work, we are exploring the signaling processes that originate from altered synaptic transmission and lead to neurodegeneration, in particular Parkinson's disease.