Research groups
Colleges
Adrian Hill
Director of the Jenner Institute, Lakshmi Mittal & Family Professor of Vaccinology, Professor of Human Genetics
Vaccines for malaria and other major diseases
Adrian V. S. Hill KBE, FRCP, FRS is the Lakshmi Mittal Professor of Vaccinology and Director of the Jenner Institute at Oxford University. In 2005 he founded the Jenner Institute at Oxford, which is now one of the largest academic vaccine centres globally with clinical-stage vaccine programmes against fifteen diseases.
His current lead malaria vaccine, R21 in matrix-M adjuvant, has shown high efficacy in clinical trials in the UK and Africa (Lancet. 2021;397:1809-1818) and could be the first widely used vaccine to impact on the great disease burden of malaria in Africa.
In Q1 2020, the Jenner Institute initiated a major effort towards rapid development of a COVID-19 vaccine which in collaboration with AstraZeneca is now in world-wide pandemic deployment.
He has published over 600 research papers with 60,000 citations and co-founded several spin-off companies. He is a Fellow of the UK Academy of Medical Sciences, the Royal College of Physicians and the Royal Society.
Recent publications
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Injectable core-shell microcapsules deliver prime-boost immunisation against malaria in a single shot
Preprint
Milicic A. et al, (2024)
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A comparative immunological assessment of multiple clinical-stage adjuvants for the R21 malaria vaccine in nonhuman primates.
Journal article
Arunachalam PS. et al, (2024), Sci Transl Med, 16
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A randomised trial of malaria vaccine R21/Matrix-M™ with and without antimalarial drugs in Thai adults.
Journal article
Hanboonkunupakarn B. et al, (2024), NPJ vaccines, 9
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Safety and immunogenicity of varied doses of R21/Matrix-M™ vaccine at three years follow-up: A phase 1b age de-escalation, dose-escalation trial in adults, children, and infants in Kilifi-Kenya
Preprint
Sang S. et al, (2024)
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High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response.
Journal article
Mentzer AJ. et al, (2024), Nature medicine