Miles Carroll
Research groups
Miles Carroll
HOST-PATHOGEN INTERACTIONS OF HIGH CONSEQUENCE EMERGING VIRUSES
Our work centres around high consequence emerging viral infections. Currently, our focus is on Ebola, Lassa fever and SARS-CoV-2. We are interested in host-pathogen interactions, development of anti-virals and recently we have been looking at the IgG response following SARS-CoV-2 infection and/or vaccination in humans and animal models. To further support this work we are using a live virus neutralisation, multiplex immunoassays and novel ACE2 inhibition assay to inform on the ability of serum to neutralise SARS-CoV-2 variants of concern (VOC). We are also interested in the innate response to viral infection, particularly activation and/or evasion of the complement system
Recent publications
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Hamsters immunized with formalin-inactivated SARS-CoV-2 develop accelerated lung histopathological lesions and Th2-biased response following infection.
Journal article
de Jong R. et al, (2025), NPJ vaccines, 10
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SARS-CoV-2 infection enhancement by amphotericin B: implications for disease management.
Journal article
Nguyen D. et al, (2025), J Virol
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Longitudinal Immunoprofiling of the CD8<sup>+</sup> T-Cell Response in SARS-CoV-2 mRNA Vaccinees and COVID-19 Patients.
Journal article
Brunetti JE. et al, (2025), Vaccines, 13
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A systems biology approach to define SARS-CoV-2 correlates of protection.
Journal article
Brady C. et al, (2025), NPJ vaccines, 10
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Silaproline-bearing nirmatrelvir derivatives are potent inhibitors of the SARS-CoV-2 main protease highlighting the value of silicon-derivatives in structure-activity-relationship studies.
Journal article
Laczi D. et al, (2025), European journal of medicinal chemistry, 291