Miles Carroll
Research groups
Miles Carroll
HOST-PATHOGEN INTERACTIONS OF HIGH CONSEQUENCE EMERGING VIRUSES
Our work centres around high consequence emerging viral infections. Currently, our focus is on Ebola, Lassa fever and SARS-CoV-2. We are interested in host-pathogen interactions, development of anti-virals and recently we have been looking at the IgG response following SARS-CoV-2 infection and/or vaccination in humans and animal models. To further support this work we are using a live virus neutralisation, multiplex immunoassays and novel ACE2 inhibition assay to inform on the ability of serum to neutralise SARS-CoV-2 variants of concern (VOC). We are also interested in the innate response to viral infection, particularly activation and/or evasion of the complement system
Recent publications
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Host-pathogen interactions of emerging zoonotic viruses: bats, humans and filoviruses.
Journal article
Hood G. and Carroll M., (2024), Current opinion in virology
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rVSV-ZEBOV vaccination in people with pre-existing immunity to Ebolavirus: an open-label safety and immunogenicity study in Guinean communities affected by Ebola virus disease (l'essai proches).
Journal article
Watson CH. et al, (2024), BMC medicine, 22
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Therapeutics for Nipah virus disease: a systematic review to support prioritisation of drug candidates for clinical trials
Journal article
Chan XHS. et al, (2024), The Lancet Microbe, 101002 - 101002
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Performance of an envelope glycoprotein-based multiplex immunoassay for Ebola virus antibody detection in a cohort of Ebola virus disease survivors.
Journal article
Roe MD. et al, (2024), Journal of virological methods, 331
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Obesity differs from diabetes mellitus in antibody and T-cell responses post-COVID-19 recovery
Journal article
Ali M. et al, (2024), Clinical and Experimental Immunology, 218, 78 - 92