Contact information

Email
mukta.deobagkar@ndm.ox.ac.uk
mukta@well.ox.ac.uk

Website
https://orcid.org/0000-0002-8543-6801

COLLABORATORS

Dr. Adán Pinto-Fernández

Dr. Katherine Bull

Mukta Deobagkar

Senior Postdoctoral Research Scientist

Research Interests

I am an immunologist with an interest in cellular immunology. I study B cell development, B cell response to antigens, and the balance between tolerance and immune activation.

I am particularly interested in the role of BCR signalling thresholds during early B cell development and during an immune challenge. Antigen affinity, avidity and form can influence B cell activation, B and T cell interactions and the generation of immune memory. Importantly, the context of antigen encounter is critical for immune cell selection and responses. However, how B cells discriminate signal quality and quantity, and how signal thresholds influence downstream molecular events to determine immune cell fate, are not very well understood. Better understanding of the cellular and molecular mechanisms underlying humoral responses in health and disease can help accelerate the development of novel immune modulators and vaccine strategies.

List of Publications

Publications from Pubmed

Differential susceptibility and maturation of thymocyte subsets during Salmonella Typhimurium infection: insights on the roles of glucocorticoids and Interferon-gamma

Majumdar S. et al, (2017), Scientific Reports, 7

Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity

Siggs OM. et al, (2016), Proceedings of the National Academy of Sciences, 113

Molecular profiling of sepsis in mice using Fourier Transform Infrared Microspectroscopy

Gautam R. et al, (2016), Journal of Biophotonics, 9, 67 - 82

Interferon-Gamma and Nitric Oxide Synthase 2 Mediate the Aggregation of Resident Adherent Peritoneal Exudate Cells: Implications for the Host Response to Pathogens

Chandrasekar BS. et al, (2015), PLOS ONE, 10, e0128301 - e0128301

c‐Jun NH2‐terminal kinase is a critical node in the death of CD4+CD8+ thymocytes during Salmonella enterica serovar Typhimurium infection

Deobagkar‐Lele M. et al, (2014), European Journal of Immunology, 44, 137 - 149

Regulation of Chemokines, CCL3 and CCL4, by Interferon γ and Nitric Oxide Synthase 2 in Mouse Macrophages and During Salmonella enterica Serovar Typhimurium Infection

Chandrasekar B. et al, (2013), The Journal of Infectious Diseases, 207, 1556 - 1568

Interferon‐γ‐ and glucocorticoid‐mediated pathways synergize to enhance death of CD4+ CD8+ thymocytes during Salmonella enterica serovar Typhimurium infection

Deobagkar‐Lele M. et al, (2013), Immunology, 138, 307 - 321

Innate immunity and the 2011 Nobel Prize

Deobagkar-Lele M. et al, (2012), Resonance, 17, 974 - 995

Identification of Early Biomarkers during Acetaminophen-Induced Hepatotoxicity by Fourier Transform Infrared Microspectroscopy

Gautam R. et al, (2012), PLoS ONE, 7, e45521 - e45521

Public Engagement

https://www.oxfordsparks.ox.ac.uk/videos/our-immune-system-the-battle-within/

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Contact information

COLLABORATORS

Mukta Deobagkar

Research Interests

List of Publications

Recent publications

B cells require DOCK8 to elicit and integrate T cell help when antigen is limiting

Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity

NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance

Author Correction: Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development

Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development

An ontogenetic switch drives the positive and negative selection of B cells

Dynamic Regulation of HIF Activity is Essential for Normal B Cell Development

An essential role for the Zn2+ transporter ZIP7 in B cell development

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

Themis2: setting the threshold for B-cell selection

Themis2 lowers the threshold for B cell activation during positive selection