Shoumo Bhattacharya
Professor of Cardiovascular Medicine
- Honorary Consultant Cardiologist
Shoumo Bhattacharya is Professor of Cardiovascular Medicine in the RDM Division of Cardiovascular Medicine at the University of Oxford and is based at the Wellcome Trust Centre for Human Genetics. He read medicine at the All India Institute of Medical Sciences in New Delhi, and trained in cardiology at Northwick Park and Hammersmith Hospitals in London, where he was also a MRC Training Fellow with James Scott working on RNA editing. He followed this with BHF and NIH Fellowships at the Dana-Farber Cancer Institute with David Livingston working on transcription factor protein interactions. He was a Wellcome Trust Senior Fellow at Oxford from 1998 to 2008, working on the transcriptional control of heart development, and their role in left-right patterning. He was elected Fellow of the Royal College of Physicians in 2003, awarded the Graham Bull Prize from the Royal College of Physicians in 2005, elected Fellow of the Academy of Medical Sciences in 2006. He was awarded a BHF Chair in 2009, and elected to a statutory Professorship at the University of Oxford in 2010. His primary role as BHF Chair has been the development of novel therapeutics and targets. The major focus of his lab is now the development of anti-inflammatory peptide therapeutics isolated from tick saliva that may have applications to myocarditis, post-myocardial infarction injury and myocardial fibrosis
Key publications
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Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling
Vales S. et al, (2023), Nature Communications, 14
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Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines
Bhusal RP. et al, (2020), Trends in Biochemical Sciences, 45, 108 - 122
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A knottin scaffold directs the CXC-chemokine–binding specificity of tick evasins
Lee AW. et al, (2019), Journal of Biological Chemistry, 294, 11199 - 11212
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The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins
Eaton JRO. et al, (2018), Journal of Biological Chemistry, 293, 6134 - 6146
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Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets
Alenazi Y. et al, (2018), Scientific Reports, 8
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Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities
Singh K. et al, (2017), Scientific Reports, 7
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VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertasePcsk5
Szumska D. et al, (2008), Genes & Development, 22, 1465 - 1477
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Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator
Bamforth SD. et al, (2001), Nature Genetics, 29, 469 - 474
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Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway
Bamforth SD. et al, (2004), Nature Genetics, 36, 1189 - 1196
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Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
Bhattacharya S. et al, (1999), Genes & Development, 13, 64 - 75
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Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α
Bhattacharya S. et al, (1996), Nature, 383, 344 - 347
Recent publications
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Mutagenesis on a complex mouse genetic background by site-specific nucleases.
Davies B. et al, (2024), Transgenic research
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Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling
Vales S. et al, (2023), Nature Communications, 14
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Calcitonin paracrine signaling controls heart fibrogenesis and arrhythmia
Moreira L. et al, (2022), JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 173, S85 - S86
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Author Correction: Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Singh K. et al, (2021), Scientific reports, 11
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Transcriptomic Analysis of Inflammatory Cardiomyopathy Identifies Molecular Signatures of Disease and Informs in silico Prediction of a Network-Based Rationale for Therapy
Singh K. et al, (2021), Frontiers in Immunology, 12
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Phylogenetic Analysis Indicates That Evasin-Like Proteins of Ixodid Ticks Fall Into Three Distinct Classes.
Bhattacharya S. and Nuttall PA., (2021), Frontiers in cellular and infection microbiology, 11
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Engineered anti-inflammatory peptides inspired by mapping an evasin–chemokine interaction
Darlot B. et al, (2020), Journal of Biological Chemistry, 295, 10926 - 10939
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Early Embryonic Expression of AP-2α Is Critical for Cardiovascular Development
Johnson A-L. et al, (2020), Journal of Cardiovascular Development and Disease, 7, 27 - 27
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Characterization of a novel inhibitor of coagulation factor XIa identified from salivary gland transcripts of the lone star tick, Amblyomma americanum.
Mrinalini None. et al, (2020), Toxicon : official journal of the International Society on Toxinology, 177 Suppl 1
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Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines
Bhusal RP. et al, (2020), Trends in Biochemical Sciences, 45, 108 - 122