Shoumo Bhattacharya
Professor of Cardiovascular Medicine
- Honorary Consultant Cardiologist
Shoumo Bhattacharya is Professor of Cardiovascular Medicine in the RDM Division of Cardiovascular Medicine at the University of Oxford and is based at the Centre for Human Genetics. He read Medicine at the All-India Institute of Medical Sciences New Delhi, qualifying MBBS 1983, and MD 1985. He worked on the immunology of rheumatic fever with Anand Malviya and Rajan Tandon for his MD Thesis. Following clinical training in Cardiology with Edward Raftery at Northwick Park Hospital, Harrow, he worked with Avijit Lahiri on myocardial imaging agents and phase-I trials of abciximab. He joined James Scott’s group at the Clinical Research Centre, Harrow as an MRC Training Fellow in 1990, and worked on the mechanism of RNA editing. In parallel, he also read Biochemistry at King's College London, obtaining a Masters degree with Distinction in 1992. With fellowships from the BHF and then the NIH, he joined David Livingston’s group at Dana-Farber Cancer Institute/ Harvard Medical School in 1994, where he worked on how viral oncoproteins target the host. Here he discovered the role of EP300/CREBBP in interferon signalling, and of CITED2 in hypoxia signalling. He continued the work on CITED2 at Oxford from 1998-2008 as a Wellcome Senior Fellow, establishing the role of this gene in left-right patterning and heart development. Here, together with Jurgen Schneider he developed high-throughput magnetic resonance microscopy for studies of cardiac development. Using this he deciphered the role of multiple genes in heart development, and the role of PCSK5 in antero-posterior patterning. He established the BHF Genetic Origins of Congenital Heart Disease Study and as a member of the UK10K Consortium contributed to the understanding of the genetics of human cardiac malformation. He was elected Fellow of the Royal College of Physicians in 2003, awarded the Graham Bull Prize of the Royal College of Physicians in 2005, elected Fellow of the Academy of Medical Sciences in 2006, awarded a BHF Chair in 2009, and elected to a Statutory Professorship of Cardiovascular Medicine at the University of Oxford in 2010. The focus of his lab since 2015 has been the development of therapeutics from naturally occurring evasin proteins from ticks that target the host chemokine network in inflammation.
Key publications
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Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling
Journal article
Vales S. et al, (2023), Nature Communications, 14
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Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines
Journal article
Bhusal RP. et al, (2020), Trends in Biochemical Sciences, 45, 108 - 122
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A knottin scaffold directs the CXC-chemokine–binding specificity of tick evasins
Journal article
Lee AW. et al, (2019), Journal of Biological Chemistry, 294, 11199 - 11212
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The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins
Journal article
Eaton JRO. et al, (2018), Journal of Biological Chemistry, 293, 6134 - 6146
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Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets
Journal article
Alenazi Y. et al, (2018), Scientific Reports, 8
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Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities
Journal article
Singh K. et al, (2017), Scientific Reports, 7
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VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertasePcsk5
Journal article
Szumska D. et al, (2008), Genes & Development, 22, 1465 - 1477
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Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator
Journal article
Bamforth SD. et al, (2001), Nature Genetics, 29, 469 - 474
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Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway
Journal article
Bamforth SD. et al, (2004), Nature Genetics, 36, 1189 - 1196
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Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
Journal article
Bhattacharya S. et al, (1999), Genes & Development, 13, 64 - 75
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Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α
Journal article
Bhattacharya S. et al, (1996), Nature, 383, 344 - 347
Recent publications
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Assessing customized multivalent chemokine-binding peptide treatment in a murine model of coxsackievirus B3 myocarditis.
Journal article
Kelm N. et al, (2025), Basic research in cardiology
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Mutagenesis on a complex mouse genetic background by site-specific nucleases.
Journal article
Davies B. et al, (2024), Transgenic research
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Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling
Journal article
Vales S. et al, (2023), Nature Communications, 14
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Calcitonin paracrine signaling controls heart fibrogenesis and arrhythmia
Conference paper
Moreira L. et al, (2022), JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 173, S85 - S86
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Author Correction: Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Journal article
Singh K. et al, (2021), Scientific reports, 11
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Transcriptomic Analysis of Inflammatory Cardiomyopathy Identifies Molecular Signatures of Disease and Informs in silico Prediction of a Network-Based Rationale for Therapy
Journal article
Singh K. et al, (2021), Frontiers in Immunology, 12
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Phylogenetic Analysis Indicates That Evasin-Like Proteins of Ixodid Ticks Fall Into Three Distinct Classes.
Journal article
Bhattacharya S. and Nuttall PA., (2021), Frontiers in cellular and infection microbiology, 11
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Engineered anti-inflammatory peptides inspired by mapping an evasin–chemokine interaction
Journal article
Darlot B. et al, (2020), Journal of Biological Chemistry, 295, 10926 - 10939
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Early Embryonic Expression of AP-2α Is Critical for Cardiovascular Development
Journal article
Johnson A-L. et al, (2020), Journal of Cardiovascular Development and Disease, 7, 27 - 27
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Characterization of a novel inhibitor of coagulation factor XIa identified from salivary gland transcripts of the lone star tick, Amblyomma americanum.
Journal article
Mrinalini None. et al, (2020), Toxicon : official journal of the International Society on Toxinology, 177 Suppl 1