Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Complications of percutaneous coronary intervention include in-stent restenosis (ISR) and in-stent thrombosis (IST) which have different underlying pathophysiological processes and different treatment strategies. ISR is primarily due to excessive neointimal growth and occurs in 20-30% of bare-metal stents (BMS). Drug-eluting stents (DES) have decreased the rates of ISR (< 10%), but are potentially associated with increased IST related to delayed arterial healing and stent strut exposure. ISR of BMS typically occurs within 6 months of stent deployment. IST usually occurs within 12 months of DES deployment. We present a case of focal ISR and IST within the same BMS, confirmed with intravascular ultrasound, 5 years after deployment in a saphenous vein graft.


Journal article


The Journal of invasive cardiology

Publication Date





E369 - E371


Department of Cardiology, Level 2, John Radcliffe Hospital, Headley Way, Headington, Oxford, Oxfordshire OX3 9DU, United Kingdom. larryponnuthurai@


Saphenous Vein, Humans, Coronary Restenosis, Myocardial Infarction, Graft Occlusion, Vascular, Coronary Angiography, Ultrasonography, Interventional, Thrombolytic Therapy, Coronary Artery Bypass, Blood Vessel Prosthesis Implantation, Follow-Up Studies, Stents, Time Factors, Middle Aged, Male, Angioplasty, Balloon, Coronary