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The mammalian globin gene clusters provide a paradigm for studying the relationship between genome structure and function. As blood stem cells undergo lineage specification and differentiation to form red blood cells, the chromatin structure and expression of the α-globin cluster change. The gradual activation of the α-globin genes in well-defined cell populations has enabled investigation of the structural and functional roles of its enhancers, promoters and boundary elements. Recent studies of gene regulatory processes involving these elements at the mouse α-globin cluster have brought new insights into the general principles underlying the three-dimensional structure of the genome and its relationship to gene expression throughout time.

Original publication

DOI

10.1016/j.gde.2020.10.003

Type

Journal article

Journal

Current opinion in genetics & development

Publication Date

04/2021

Volume

67

Pages

18 - 24

Addresses

Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. Electronic address: marieke.oudelaar@mpibpc.mpg.de.

Keywords

Chromatin, Animals, Mice, Gene Expression Regulation, Regulatory Sequences, Nucleic Acid, Genome, Promoter Regions, Genetic, alpha-Globins