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This application claims a new method for diagnosis, prognosis and treatment of cancer using a non-invasive technique, the analysis of free circulating DNA in body fluids as a biomarker. The claimed procedure is based on the analysis of gene promoter methylation status and DNA integrity and concentration in the body fluid. Interestingly, DNA isolation from complex milieus is not required.

Original publication




Journal article


Expert opinion on medical diagnostics

Publication Date





143 - 146


Hospital General Universitario de Valencia Servicio de Oncología Médica and Laboratorio de Oncología Molecular, Av. Tres Cruces s/n, 46014 Valencia, Spain +34 961 972 151 ; +34 961 972 151 ; camps_car@gva.escologìa Molecular, Fundación Investigación, Hospital General Universitario, Valencia, Spain.