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We present a case of a patient with non-resected epidermoid carcinoma of the anal canal, treated with a combination of radiotherapy regional and chemotherapy according to MMC-Ufelos protocol. After the application of the fourth chemotherapy cycle, the patient presented microangiopathic hemolytic anemia associated to Mitomycin-C, which was treated with the application of recurrent plasmapheresis and restricted transfusions of red corpuscles concentrate. The physiopathology of this disorder and its therapeutical implications are review.


Journal article


Anales de medicina interna (Madrid, Spain : 1984)

Publication Date





611 - 613


Servicio de Medicina Interna, Hospital General Universitario, Valencia.


Humans, Anemia, Hemolytic, Mitomycin, Middle Aged, Male, Acute Kidney Injury