Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL
Iacovelli S., Hug E., Bennardo S., Duehren-von Minden M., Gobessi S., Rinaldi A., Suljagic M., Bilbao D., Bolasco G., Eckl-Dorna J., Niederberger V., Autore F., Sica S., Laurenti L., Wang H., Cornall RJ., Clarke SH., Croce CM., Bertoni F., Jumaa H., Efremov DG.
Key Points Cell autonomous BCR interactions and interactions with low-affinity autoantigens drive leukemia development in an in vivo model of CLL. BCR signals induced by binding to external antigen can increase the aggressiveness of CLL.