First Report of bla IMP-14 on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131
Stoesser N., Sheppard AE., Peirano G., Sebra RP., Lynch T., Anson LW., Kasarskis A., Motyl MR., Crook DW., Pitout JD.
ABSTRACT The bla IMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli , we identified a sequence type 131 strain harboring bla IMP-14 within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C 2 plasmid. The emergence of bla IMP-14 in this context in the ST131 lineage is of potential clinical concern.