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ABSTRACT OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced bla OXA-163 plasmid and of two other bla OXA-48 plasmids in this lineage. bla OXA-163 was located on a 71-kb IncN plasmid with other resistance genes. bla OXA-48 was present on IncL/M plasmids, genetically similar to other bla OXA-48 plasmid sequences, and consistent with interspecies/interlineage spread. The presence of bla OXA-48-like genes on epidemic plasmids in ST131 is of concern.

Original publication




Journal article


Antimicrobial Agents and Chemotherapy


American Society for Microbiology

Publication Date





6948 - 6951