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Analysis of copy number variants of the duplicated alpha-, zeta-, and gamma-globin genes in eastern Polynesians revealed a high frequency of both triplicated-zeta-gene chromosomes and a specific alpha thalassemia deletion. This deletion and a novel restriction-enzyme-site polymorphism associated with a zeta zeta zeta chromosome are found only in Melanesians and Polynesians. Analysis of alpha-globin restriction-enzyme haplotypes indicated further similarities to Melanesians but suggested an additional non-Melanesian genetic component in eastern Polynesia. Several globin gene alleles showed evidence of marked frequency fluctuations due to genetic drift.

Type

Journal article

Journal

American journal of human genetics

Publication Date

05/1987

Volume

40

Pages

453 - 463

Keywords

Humans, Globins, Genetic Markers, Genetics, Population, Gene Frequency, Polymorphism, Restriction Fragment Length, Alleles, Polynesia, Genetic Variation