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Screening a human small intestinal library with human serum yielded a clone which encoded a protein res4‐22 the gene of which was highly homologous to a recently described gene located in the Huntington's disease locus. Autoantibodies against res4‐22 (anti‐res4‐22), mainly of the immunoglobulin (Ig)A type, were detected in patients with neurological disorders at a higher frequency (18.4%) than in healthy blood donors (8.0%). In neurological patients with cerebral ischaemia anti‐res4‐22 was found significantly more often (47.4%) than in the total group of neurological patients. Anti‐res4‐22 positive sera showed significantly more frequently myelin staining in cerebellum and nerve sections than anti‐res4‐22 negative sera. Our findings demonstrate a new species of human autoantibodies against a newly described protein the function of which is still unknown.

Original publication

DOI

10.1046/j.1365-3083.2001.00839.x

Type

Journal article

Journal

Scandinavian Journal of Immunology

Publisher

Wiley

Publication Date

02/2001

Volume

53

Pages

204 - 208