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Mapping structural and dynamic divergence across the MBOAT family.

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Ansell TB. et al, (2024), Structure (London, England : 1993)

Diverse genetic causes of amenorrhea in an ethnically homogeneous cohort and an evolving approach to diagnosis.

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Bakhshalizadeh S. et al, (2024), Molecular and cellular endocrinology

Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.

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Ritzefeld M. et al, (2024), Journal of medicinal chemistry

The energetics and ion coupling of cholesterol transport through Patched1

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Ansell TB. et al, (2023), Science Advances, 9

Rocking the MBOAT: Structural insights into the membrane bound O-acyltransferase family.

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Coupland CE. et al, (2023), Curr Opin Struct Biol, 80

The Inseparable Relationship Between Cholesterol and Hedgehog Signaling.

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Siebold C. and Rohatgi R., (2023), Annu Rev Biochem

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

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Griffiths SC. et al, (2021), Nature Communications, 12

Structure, mechanism, and inhibition of Hedgehog acyltransferase

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Coupland CE. et al, (2021), Molecular Cell, 81, 5025 - 5038.e10

Relative Affinities of Protein–Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations

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Ansell TB. et al, (2021), Journal of Chemical Theory and Computation, 17, 6548 - 6558

Structure and Mechanism of Hedgehog Acyl Transferase

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Coupland CE. et al, (2021)

Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)**

Journal article

Lanyon‐Hogg T. et al, (2021), Angewandte Chemie, 133, 13654 - 13659

Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*.

Journal article

Lanyon-Hogg T. et al, (2021), Angewandte Chemie (International ed. in English), 60, 13542 - 13547

Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.

Journal article

Robinson RA. et al, (2021), Cell, 184, 2103 - 2120.e31

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