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Publications

Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C.

Beagrie RA. et al, (2023), Nature methods

Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks.

Jung MM. et al, (2023), The Journal of clinical investigation, 133

Gene silencing dynamics are modulated by transiently active regulatory elements.

Vermunt MW. et al, (2023), Molecular cell, 83, 715 - 730.e6

Making connections: enhancers in cellular differentiation

Herrmann JC. et al, (2022), Trends in Genetics, 38, 395 - 408

Scalable in vitro production of defined mouse erythroblasts.

Francis HS. et al, (2022), PloS one, 17

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

Downes DJ. et al, (2021), Nature Communications, 12

Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities.

Scott C. et al, (2021), Haematologica, 106, 2960 - 2970

Reactivation of a developmentally silenced embryonic globin gene.

King AJ. et al, (2021), Nature communications, 12

The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization.

Oudelaar AM. et al, (2021), Current opinion in genetics & development, 67, 18 - 24

Enhancers predominantly regulate gene expression during differentiation via transcription initiation.

Larke MSC. et al, (2021), Molecular cell, 81, 983 - 997.e7

Dynamics of the 4D genome during in vivo lineage specification and differentiation

Oudelaar AM. et al, (2020), Nature Communications, 11

Hypoxia Induces Transcriptional and Translational Downregulation of the Type I IFN Pathway in Multiple Cancer Cell Types.

Miar A. et al, (2020), Cancer research, 80, 5245 - 5256

Multiplex-GAM: genome-wide identification of chromatin contacts yields insights not captured by Hi-C

Beagrie RA. et al, (2020)

Dynamics of the 4D genome during lineage specification, differentiation and maturation in vivo

Oudelaar M. et al, (2019)

Modelling erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I)

Scott C. et al, (2019)

Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types

Miar A. et al, (2019)

Continuous chromatin changes

Beagrie RA. and Pombo A., (2017), Nature, 547, 34 - 35

GAMtools: an automated pipeline for analysis of Genome Architecture Mapping data

Beagrie R. and Schueler M., (2017)

Complex multi-enhancer contacts captured by genome architecture mapping

Beagrie RA. et al, (2017), Nature, 543, 519 - 524

Examining Topological Domain Influence on Enhancer Function

Beagrie RA. and Pombo A., (2016), Developmental Cell, 39, 523 - 524

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