DPhil awarded 2013
Now (January 2018): MRC Intermediate Research Fellow in Computational Biology and Epidemiology, Faculty of Medicine, School of Public Health, Imperial College, London.
Functional genomics of Vitamin D
I am interested in trying to understand gene environment interactions, particularly the effects of vitamin D on genes associated with multiple sclerosis (MS) and other autoimmune conditions, and with severe sepsis.
Epidemiological evidence points towards an effect for vitamin D in the susceptibility and clinical course of several diseases. Latitude, diet, migration, month of birth, serum levels of vitamin D and other factors have been shown to influence MS. Work carried out in the Julian Knight and George Ebers groups showed a functional genetic link between vitamin D and the main susceptibility locus for MS, HLA-DRB1*1501 (Ramagopalan et al. PLoS Genetics 2009).
My research aims to elucidate the molecular mechanisms behind these interactions. My background includes a medical degree (UNAM, Mexico) and an MSc (University of Oxford). I am currently completing a DPhil as part of the Knight and Ebers labs at the University of Oxford funded by CONACyT, Mexico and the Multiple Sclerosis Societies of UK and Canada.
Keywords: Vitamin D, Multiple Sclerosis, autoimmunity
Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Handunnetthi L, Orton S, Handel AE, Watson CT, Morahan JM, Giovannoni G, Ponting CP, Ebers GC, Knight JC. 2010 A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Research 20, 1352-1360 View in PubMed