following the publication of the new paper Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia. Burnham KL, Davenport EE, Radhakrishnan J, Humburg P, Gordon AC, Hutton P, Svoren-Jabalera E, Garrard C, Hill AV, Hinds CJ, Knight JC. American Journal of Respiratory and Critical Care Medicine, online pre-print December 2016 PMID: 28036233
Sepsis is a highly heterogeneous syndrome, in which we have applied genomic approaches to gain insight into the individual response to infection. This paper describes the gene expression response to abdominal sepsis, investigating individual and temporal variation in the gene expression patterns observed, and comparing this to pneumonia. We found that sepsis response signature (SRS) subgroups were present in faecal peritonitis, replicating the association of relative immunosuppression with increased early mortality previously described in pneumonia. Differences according to source of infection were less pronounced, but changes in gene expression over time were noted. These findings highlight the opportunity for personalised medicine in sepsis.
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