Congratulations to Julie Osgood on the publication of her review paper "Translating GWAS in rheumatic disease: approaches to establishing mechanism and function for genetic associations with ankylosing spondylitis"
Julie A Osgood, Julian C Knight, Briefings in Functional Genomics, 2018, ely015. https://doi.org/10.1093/bfgp/ely015
Ankylosing spondylitis (AS) is a highly heritable chronic inflammatory arthritis characterized by osteoproliferation, fusion of affected joints and systemic manifestations. Many disease associations for AS have been reported through genome-wide association studies; however, identifying modulated genes and functional mechanism remains challenging. This review summarizes current genetic associations involving AS and describes strategic approaches for functional follow-up of disease-associated variants.