Alumni Profile: Abed Refaee (2023-2024)

WHY DID YOU CHOOSE THE MSC IN GENOMIC MEDICINE AT OXFORD?

I was drawn to the MSc in Genomic Medicine at Oxford for its emphasis on integrating quantitative methods with genetic and genomic research. The program fosters an interdisciplinary environment, allowing for the application of data-driven methods to answer novel biological questions. The opportunity to work within leading research groups made it an ideal choice to develop expertise in genomics, bioinformatics, and computational biology.

WHAT WERE THE HIGHLIGHTS OF THE MSC IN GENOMIC MEDICINE FOR YOU?

One of the biggest highlights of the MSc was the opportunity to be immersed in a highly interdisciplinary and collaborative research environment. Engaging with leading researchers and attending guest lectures from experts at the forefront of genomics research was inspiring and stimulating. Additionally, I gained valuable insights into the translation of health research into clinical applications, bridging the gap between scientific discovery and patient care. The program also provided exposure to various career pathways beyond academia and research, broadening my understanding of potential professional opportunities in industry, healthcare, and policy. Furthermore, studying alongside a diverse cohort, both academically and internationally, enriched my learning experience by fostering cross-disciplinary discussions and global perspectives on genomic medicine.

WHICH SPECIFIC ADVANCED ELECTIVE MODULES DID YOU CHOOSE, AND WHY?

I selected Advanced Quantitative Methods (Bioinformatics and Statistics), Genome Engineering and Gene-based Therapeutics, and Application of Genomics for Therapeutics, Vaccinology and Industry as my elective modules.

Advanced Bioinformatics and Statistics provided me with a deeper understanding of computational methodologies and statistical frameworks, which were essential for taking on bioinformatics research. This module highlighted the importance of exploring and utilising existing genomic datasets to derive new research, answer novel questions, and approach existing problems from different perspectives. Additionally, it emphasised how data-driven insights can contribute to improving clinical practice and patient outcomes.

Genome Engineering and Gene-based Therapeutics was particularly appealing due to my interest in learning about functional genomics and gene-editing technologies, which are transforming precision medicine. This area of research holds great potential in providing cures for many debilitating genetic diseases that were previously difficult to understand or manage.

Application of Genomics for Therapeutics, Vaccinology and Industry offered insights into the translational aspect of genomic research, providing an understanding of the real-world applications of genomic medicine in treatment and vaccine development, and clinical trial design. This module also emphasised the impact of pharmacogenetics on optimising clinical trial design and improving the efficacy and safety of proposed treatments, further highlighting the role of genomics in advancing personalised medicine.

TELL US ABOUT YOUR MSC RESEARCH PROJECT AND HOW IT CONTRIBUTED TO YOUR UNDERSTANDING OF GENOMICS AND RESEARCH SKILLS.

My MSc thesis focused on the landscape of de novo structural variants (SVs). I developed and implemented computational workflows to detect and analyse de novo mutations, utilising cutting-edge bioinformatics tools.

Through this project, I honed my expertise in:

High-throughput genomic data analysis using Python, R, and Bash.

Variant calling and annotation pipelines.

Deploying bioinformatics tools on high-performance computing (HPC) clusters.

This experience strengthened my problem-solving skills and ability to handle large-scale genomic datasets. 

HOW DO YOU ENVISION THE MSC IN GENOMIC MEDICINE BENEFITING YOUR FUTURE CAREER OR ACADEMIC PURSUITS? 

The MSc program provided me with a strong foundation in genomic medicine and computational biology, both of which are vital to my current PhD research which focuses on investigating effects of genetic mutations on protein aggregation in Motor Neuron Disease (MNDs). Both the theoretical knowledge and the analytical and computational skills I acquired during my MSc are directly applicable to my current research; furthermore, the MSc also prepared me for the rigorous scientific inquiry and collaborative research necessary for a successful career in both academia and healthcare industry. 

IF YOU COULD OFFER ADVICE TO PROSPECTIVE STUDENTS CONSIDERING THE MSC IN GENOMIC MEDICINE AT OXFORD, WHAT WOULD IT BE?

Engage with Faculty and Peers: Take advantage of the opportunity to interact with leading experts in genomic research and work alongside your peers. 

Build Your Computational Skills: Given the importance of utilising existing healthcare data and the increasing reliance on bioinformatics, developing proficiency in programming (Python, R) and statistical methods will be invaluable. 

Explore the Diverse Range of Modules: The course offers a broad selection of modules covering clinical, computational, and biology-focused topics. My advice is to step out of your comfort zone and select modules that intrigue you, even if you lack prior experience. The teaching team provides hands-on support, ensuring you gain confidence and practical skills in new areas.

Make the Most of Research Opportunities: The MSc project is a great opportunity to gain hands-on experience and shape your future career. The research project offers an experience akin to a real-world research environment, helping develop critical thinking, problem-solving, and independent research skills crucial for both academic and industry settings. Additionally, it provides the opportunity to work within a research team, fostering collaboration and allowing you to contribute insights to the broader goals of the group, thereby gaining a deeper understanding of the collective research process.