Research groups
Marcos Garcia-Lacarte
PhD
Senior Bioinformatician
Identification of tumor-derived neoepitopes as potential vaccine candidates in Lynch Syndrome patients
RESEARCH PROFILE
I work at the intersection of immunology, genomics, and data science, with a special focus on cancer research. I have a strong background in T cell profiling and a multidisciplinary skill set that combines wet-lab experimentation with advanced computational analysis, particularly in studying immune–tumor interactions.
Currently, I’m a bioinformatician in the Church group at the Centre for Human Genetics, University of Oxford, where I lead data analysis for the LynchVax project—an initiative aimed at developing a preventive cancer vaccine for individuals with Lynch Syndrome. I integrate multi-omics data (WGS, WES, RNA-seq, spatial transcriptomics, proteomics) to analyze T cell function and identify tumor-derived neoepitopes as potential vaccine candidates. Additionally, I also develop analytical tools and pipelines, contribute to scientific publications, and support data infrastructure across the project.
BIOGRAPHY
I am a multidisciplinary researcher with extensive experience at the intersection of immunology, genomics, and data science. Trained as a biotechnologist, I later specialized in transcriptomic biomarkers and cancer immunology at the University of Navarra. My career spans both wet-lab and computational research, with strong hands-on expertise in molecular biology, next-generation sequencing, and preclinical models.
Throughout my trajectory, I have led and contributed to research projects investigating immune evasion in cancer, particularly in lymphomas. By integrating transcriptomic and immunological profiling techniques, my work has aimed to elucidate tumor–immune interactions and support the development of novel therapeutic strategies.
Recent publications
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IL-10 from tumoral B cells modulates the diffuse large B-cell lymphoma microenvironment and response to immunotherapy
Garcia-Lacarte M. et al, (2025), Blood Journal
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Fecal microbiota transplantation from female donors restores gut permeability and reduces liver injury and inflammation in middle-aged male mice exposed to alcohol
Lamas-Paz A. et al, (2024), Frontiers in Nutrition, 11
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Venetoclax improves CD20 immunotherapy in a mouse model of MYC/BCL2 double-expressor diffuse large B-cell lymphoma
Melchor J. et al, (2023), Journal for ImmunoTherapy of Cancer, 11, e006113 - e006113
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The PD-1/PD-L1 Checkpoint in Normal Germinal Centers and Diffuse Large B-Cell Lymphomas
Garcia-Lacarte M. et al, (2021), Cancers, 13, 4683 - 4683